COPD Is Associated with Elevated IFN-β Production by Bronchial Epithelial Cells Infected with RSV or hMPV

IFN treatment may be a viable option for treating COPD exacerbations based on evidence of deficiency in COPD. However, vitro studies have used primarily influenza and rhinoviruses to investigate responses. This study aims the susceptibility infection response primary bronchial epithelial cells (BECs) from donors with RSV hMPV. BECs five healthy were establish both submerged monolayer well-differentiated (WD) cultures. Two isolates hMPV infect cells. was not associated elevated there no an intrinsic defect production either cell model virus. Conversely, significantly IFN-β viruses models. Only WD-BECs infected reduced viral shedding. The role pathogenesis is clear warrants further investigation. Viruses vary responses that they induce BECs, so conclusions regarding antiviral disease cannot made single infections.